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Ultraviolet Radiation Damage in DNA
Introduction The evolution of most forms of life has occurred in an environment exposed to the ultraviolet (UV) and visible radiation emanating from the sun. When molecules in living cells absorb photons in this region of the electromagnetic spectrum they are promoted to excited electronic states and this process can have profound biological consequences. In general, visible wavelengths (400-78...
full textRadiation-induced DNA damage responses.
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA rep...
full textRadiation Dose-Rate and DNA Damage
In their article, Olipitz et al. (2012) examined signs of DNA damage after chronic exposure of C57Bl6 mice to low-level ionizing radiation (3 mGy/day). For 5 weeks, mice were irradiated continuously with 35.5 keV X-rays produced by the decay of iodine-125, yielding an accumulated dose of 105 mGy. The observed effects were compared with those from acute irradiation by X-ray machine at 1,700 mGy/...
full textRadiation damage to DNA-protein complexes
We review here the advances in understanding the effects of ionizing radiations on DNA, proteins and their complexes, resulting from the collaboration of the authors’ teams. It concerns the preponderant indirect effect of low LET ionizing radiations, thus the attack of the macromolecules in aqueous solution by the most aggressive product of water radiolysis, the hydroxyl radical. A model of sim...
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Journal title
volume 1 issue None
pages 14- 17
publication date 2003-06
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